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Pantethine, a derivative of pantothenic acid (vitamin B5), is directly involved in the production of coenzyme A(CoA).  CoA is a helper molecule that facilitates oxidation which is involved in the metabolism of fat, cholesterol, carbohydrates, and amino acids.  Additional helpful properties of pantethine, include:

  • Lowering apolipoprotein B up to 27.6 percent
  • Increasing apolipoprotein A-I
  • Boosting HDL (good cholesterol) quantity and quality while lowering triglycerides
  • Reducing the deposition of fats and the development of fatty streaks in the aorta and coronary arteries.
  • Slowing the oxidation of LDL into its more dangerous form.

A number of studies have been performed to show the effects of pantethine.  Patients with high cholesterol were given 900 mg of pantethine per day.  It resulted in a 13.5 percent decrease in the total and LDL cholesterol levels, and a 30 percent decrease in triglycerides.  Conversely, HDL levels were boosted by 10 percent.

In another study, 12 stroke survivors were given 1,000 mg of pantethine per day for 90 days.  Total cholesterol, LDL, VLDL, and triglycerides decreased, while HDL increased.  Of particular importance was the fact that HDL2 increased.  Within the HDL is a key protein called Apo-A1 protein which increases anti-inflammatory and antioxidant activity.  Pantethine boosts the concentration of this protein, which leads to the improved extrication of plaque-forming LDL and lowers the risk of a stroke.

Similarly, 18 patients (nine men and nine women, average age 52) were given 800 mg of pantethine per day and another group of 65 adults and seven children with high cholesterol, were given 90-1,200mg per day for three to six months. Again, total cholesterol and triglycerides were reduced while HDL and Apo-A1 were increased.  

A postmarketing analysis of more than 1,000 patients (many with type I and type II diabetes) who were given 900 mg of pantethine per day, found similar improvements in the lipid profiles, with no noticeable side effects.

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